Neural Darwinism: selection and reentrant signaling in higher brain function

Neuron. 1993 Feb;10(2):115-25. doi: 10.1016/0896-6273(93)90304-a.


Variation and selection within neural populations play key roles in the development and function of the brain. In this article, I review a population theory of the nervous system aimed at understanding the significance of these processes. Since its original formulation in 1978, considerable evidence has accumulated to support this theory of neuronal group selection. Extensive neural modeling based on the theory has provided useful insights into several outstanding neurobiological problems including those concerned with integration of cortical function, sensorimotor control, and perceptually based behavior.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Brain / physiology*
  • Models, Biological
  • Motor Activity / physiology
  • Neuronal Plasticity
  • Neurons / physiology
  • Neurotransmitter Agents / physiology
  • Selection, Genetic*
  • Signal Transduction*


  • Neurotransmitter Agents