Modulation of bradykinin-induced plasma extravasation in the rat knee joint by sympathetic co-transmitters

Neuroscience. 1993 Jan;52(2):451-8. doi: 10.1016/0306-4522(93)90171-b.


We describe the contribution of various sympathetic post-ganglionic neuron mediators to bradykinin-induced plasma extravasation in the knee joint of the rat. Co-perfusion of the sympathetic post-ganglionic neuron mediators, norepinephrine or neuropeptide Y with bradykinin resulted in diminished plasma extravasation. In contrast, the putative sympathetic post-ganglionic neuron mediators of bradykinin-induced plasma extravasation, namely prostaglandin E2, ATP, the selective adenosine A2-receptor agonist, CGS21680 or the endothelium-derived relaxing factor (as its precursor L-arginine) all greatly enhanced bradykinin-induced plasma extravasation, but produced little or no increase in plasma extravasation administered alone. The data show that sympathetic post-ganglionic neuron-derived mediators may either inhibit or enhance plasma extravasation induced by bradykinin, and we hypothesize that differential release of mediators from the sympathetic post-ganglionic neuron terminal, in response to varying stimuli, regulates local plasma extravasation during inflammation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine / analogs & derivatives
  • Adenosine / pharmacology
  • Adenosine Triphosphate / pharmacology
  • Animals
  • Antihypertensive Agents / pharmacology
  • Arginine / pharmacology
  • Arthritis / drug therapy
  • Arthritis / physiopathology*
  • Bradykinin / antagonists & inhibitors*
  • Bradykinin / pharmacology
  • Dinoprostone / pharmacology
  • Male
  • Neuropeptide Y / pharmacology
  • Neurotransmitter Agents / pharmacology*
  • Norepinephrine / pharmacology
  • Oxidopamine
  • Phenethylamines / pharmacology
  • Platelet Activating Factor / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Sympathectomy, Chemical
  • Sympathetic Nervous System / physiology*


  • Antihypertensive Agents
  • Neuropeptide Y
  • Neurotransmitter Agents
  • Phenethylamines
  • Platelet Activating Factor
  • 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine
  • Oxidopamine
  • Adenosine Triphosphate
  • Arginine
  • Adenosine
  • Dinoprostone
  • Bradykinin
  • Norepinephrine