Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system

Nature. 1993 Mar 25;362(6418):312-8. doi: 10.1038/362312a0.

Abstract

Glial growth factors, proteins that are mitogenic for Schwann cells, and several ligands for the p185erbB2 receptor, are products of the same gene. Alternative splicing of the messenger RNA generates an array of putative membrane-attached, intracellular and secreted signalling proteins, at least some of which are expressed in the developing spinal cord and brain. These factors are probably important in the development and regeneration of the nervous system.

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / physiology*
  • Cattle
  • Cells, Cultured
  • Cloning, Molecular
  • Glia Maturation Factor
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / metabolism*
  • Oncogene Proteins, Viral / metabolism*
  • Organ Specificity
  • Phosphorylation
  • RNA, Messenger / metabolism
  • Receptor, ErbB-2
  • Schwann Cells / metabolism*
  • Spinal Cord / physiology*

Substances

  • Glia Maturation Factor
  • Nerve Tissue Proteins
  • Oncogene Proteins, Viral
  • RNA, Messenger
  • Receptor, ErbB-2