Active suppression induced by anti-CD4

Eur J Immunol. 1993 Apr;23(4):965-8. doi: 10.1002/eji.1830230431.


Treatment with a non-depleting monoclonal antibody to CD4 in the presence of mouse thyroglobulin (MTg) inhibits the development of murine autoimmune thyroiditis. This unresponsiveness was transferrable since such treatment generated a population of donor cells which could suppress the thyroiditis induced in lightly irradiated recipients by subsequent challenge with specific antigen. The suppression appears to be both antigen specific and antigen dependent and seems to discriminate between TH1 and TH2 helper subsets in that there is no significant effect on anti-MTg autoantibodies after challenge.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibody Formation
  • Antigen-Antibody Reactions
  • CD4 Antigens / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Female
  • Immune Tolerance*
  • Immunity, Cellular
  • Immunization, Passive
  • Male
  • Mice
  • Mice, Inbred CBA
  • T-Lymphocytes, Regulatory / immunology*
  • Thyroglobulin / immunology
  • Thyroiditis, Autoimmune / immunology


  • CD4 Antigens
  • Thyroglobulin