The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis

Cell. 1993 Apr 9;73(1):159-68. doi: 10.1016/0092-8674(93)90168-p.


To identify genes involved in vascular disease, we investigated patients with supravalvular aortic stenosis (SVAS), an inherited vascular disorder that causes hemodynamically significant narrowing of large elastic arteries. Pulsed-field gel and Southern analyses showed that a translocation near the elastin gene cosegregated with SVAS in one family. DNA sequence analyses demonstrated that the translocation disrupted the elastin gene and localized the breakpoint to exon 28. Taken together with our previous study linking SVAS to the elastin gene in two additional families and existing knowledge of vascular biology, these data suggest that mutations in the elastin gene can cause SVAS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Aortic Valve Stenosis / genetics*
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6
  • Chromosomes, Human, Pair 7
  • Elastin / genetics*
  • Female
  • Genetic Linkage
  • Humans
  • Hybrid Cells
  • Male
  • Molecular Sequence Data
  • Pedigree
  • Polymorphism, Restriction Fragment Length
  • Syndrome
  • Translocation, Genetic


  • Elastin

Associated data

  • GENBANK/L09220
  • GENBANK/L09221
  • GENBANK/L09222
  • GENBANK/L09223
  • GENBANK/L09224
  • GENBANK/L09225
  • GENBANK/L33709
  • GENBANK/S57887
  • GENBANK/S63764
  • GENBANK/S63803