A TH1-->TH2 Switch Is a Critical Step in the Etiology of HIV Infection

Immunol Today. 1993 Mar;14(3):107-11. doi: 10.1016/0167-5699(93)90208-3.

Abstract

This viewpoint proposes that an imbalance in the TH1-type and TH2-type responses contributes to the immune dysregulation associated with HIV infection, and that resistance to HIV infection and/or progression to AIDS is dependent on a TH1-->TH2 dominance. This hypothesis is based on the authors' findings that: (1) progression to AIDS is characterized by loss of IL-2- and IFN-gamma production concomitant with increases in IL-4 and IL-10; and (2) many seronegative, HIV-exposed individuals generate strong TH1-type responses to HIV antigens.

Publication types

  • Review

MeSH terms

  • AIDS Vaccines / administration & dosage
  • AIDS Vaccines / immunology
  • Acquired Immunodeficiency Syndrome / immunology
  • Acquired Immunodeficiency Syndrome / pathology
  • Animals
  • CD4-Positive T-Lymphocytes / pathology*
  • HIV Infections / immunology*
  • HIV Infections / pathology
  • Haplorhini
  • Humans
  • Immunization / methods
  • Interferon-gamma / biosynthesis
  • Interleukins / biosynthesis
  • Male
  • Mice
  • Models, Biological
  • Simian Immunodeficiency Virus / immunology
  • T-Lymphocytes, Helper-Inducer / pathology*

Substances

  • AIDS Vaccines
  • Interleukins
  • Interferon-gamma