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, 260 (5105), 214-6

Taxol and Taxane Production by Taxomyces Andreanae, an Endophytic Fungus of Pacific Yew

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Taxol and Taxane Production by Taxomyces Andreanae, an Endophytic Fungus of Pacific Yew

A Stierle et al. Science.

Abstract

Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia. The fungus is hyphomyceteous and, when grown in a semi-synthetic liquid medium, produced taxol and related compounds. Taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol. Both [1-14C]acetic acid and L-[U-14C]phenylalanine served as precursors of [14C]taxol in fungal cultures. No taxol was detected in zero-time cultures or in the small agar plugs used to inoculate the culture flasks.

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