Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules

J Med Chem. 1993 Feb 19;36(4):513-5. doi: 10.1021/jm00056a013.

Authors

J M Carboni¹, V Farina, S Rao, S I Hauck, S B Horwitz, I Ringel

Affiliation

¹ Department of Experimental Therapeutics, and Antitumor Chemistry, Bristol Myers Squibb Research Institute, Wallingford, Connecticut 06492.

PMID: 8097253
DOI: 10.1021/jm00056a013

No abstract available

MeSH terms

Adenocarcinoma
Affinity Labels / chemical synthesis*
Animals
Binding Sites
Binding, Competitive
Cell Line
Colonic Neoplasms
Fluorescent Antibody Technique
Mice
Microtubules / metabolism*
Paclitaxel / analogs & derivatives*
Paclitaxel / metabolism*
Photochemistry
Tumor Cells, Cultured

Substances

Affinity Labels
Paclitaxel