Transcriptional activation of Drosophila homeotic genes from distant regulatory elements

Trends Genet. 1993 Mar;9(3):75-9. doi: 10.1016/0168-9525(93)90227-9.


In Drosophila the genes responsible for specifying segment identity (the homeotic genes) are transcribed in complex patterns during development. Mutations that mimic loss of homeotic gene activity identify cis-acting DNA sequences and trans-acting proteins required for transcriptional activation. Some of the trans-acting proteins may facilitate interactions between cis-regulatory elements and the promoter by bringing together distant chromosomal elements.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Drosophila / genetics*
  • Gene Expression Regulation
  • Genes, Homeobox*
  • Molecular Sequence Data
  • Regulatory Sequences, Nucleic Acid*
  • Sequence Homology, Amino Acid
  • Trans-Activators
  • Transcription, Genetic*


  • Trans-Activators