The molecular basis of the human serum paraoxonase activity polymorphism

Nat Genet. 1993 Jan;3(1):73-6. doi: 10.1038/ng0193-73.


The organophosphate cholinesterase inhibitor paraoxon is hydrolysed by serum paraoxonase/arylesterase. A genetic polymorphism of paraoxonase (PON) activity which determines high versus low paraoxon hydrolysis in human populations, may determine sensitivity to parathion poisoning. We demonstrate that arginine at position 192 specifies high activity PON whereas a glutamine specifies the low activity variant. Allele-specific probes or restriction enzyme analysis of amplified DNA allow for the genotyping of individuals. PON maps to chromosome 7q21-22, proximal to the cystic fibrosis gene, in agreement with previous genetic linkage studies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aryldialkylphosphatase
  • Base Sequence
  • Chromosomes, Human, Pair 7
  • Cloning, Molecular
  • DNA
  • Humans
  • Molecular Sequence Data
  • Paraoxon*
  • Phosphoric Monoester Hydrolases / blood
  • Phosphoric Monoester Hydrolases / genetics*
  • Polymorphism, Restriction Fragment Length


  • DNA
  • Phosphoric Monoester Hydrolases
  • Aryldialkylphosphatase
  • Paraoxon