Apoptosis and disease

Lancet. 1993 May 15;341(8855):1251-4. doi: 10.1016/0140-6736(93)91154-e.


The intercellular connections that characterise advanced forms of life would not be possible without a mechanism to remove individual cells that are no longer needed, or that function abnormally. Such physiological cell death, in the absence of inflammation, is achieved by apoptosis, a structurally distinct programmed cell death pathway. Defective regulation of programmed cell death may play a part in the aetiology of cancer, AIDS, autoimmune diseases, and degenerative diseases of the central nervous system. The pharmacological manipulation of apoptosis offers new possibilities for the prevention and treatment of these illnesses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / physiopathology
  • Aging / physiology
  • Animals
  • Apoptosis* / physiology
  • Autoimmune Diseases / physiopathology
  • Humans
  • Neoplasms / physiopathology*