Dosaging patterns in schizophrenia with depot, oral and combined neuroleptic therapy

Can J Psychiatry. 1993 Apr;38(3):159-61. doi: 10.1177/070674379303800301.


A group of patients with chronic schizophrenia were evaluated according to the form of neuroleptic treatment they were receiving: depot, oral or combined (depot/oral or oral/oral). The patients treated with the combined therapy received significantly higher dosages of neuroleptic than those treated with either depot or oral therapy, which did not differ from each other. Daily maintenance dosages were generally well above recent guidelines.

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Adult
  • Antipsychotic Agents / administration & dosage*
  • Delayed-Action Preparations
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Schizophrenia / drug therapy*
  • Schizophrenic Psychology*


  • Antipsychotic Agents
  • Delayed-Action Preparations