Exocrine pancreatic response to intraduodenal fatty acids and fats in rabbits

Comp Biochem Physiol Comp Physiol. 1993 May;105(1):141-5. doi: 10.1016/0300-9629(93)90186-8.


1. The exocrine pancreatic secretion in rabbits after intraduodenal perfusion of, respectively, a short-chain fatty acid (propionate), a long-chain fatty acid (oleate) and a neutral fat (intralipid) has been studied. 2. Only the neutral fat and the long-chain fatty acid stimulated the hydroelectrolyte fraction of exocrine pancreatic secretion in a dose-related fashion, but this response was not mediated by secretin release. 3. Acinar secretion was more effectively stimulated after propionate perfusion than by oleate and this was governed by different mechanisms. 4. Neutral fat, without predigestion, stimulated the pancreatic enzyme secretion in the rabbit.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Bicarbonates / metabolism
  • Duodenum / metabolism*
  • Fat Emulsions, Intravenous / metabolism*
  • Male
  • Oleic Acid
  • Oleic Acids / metabolism*
  • Pancreas / metabolism*
  • Propionates / metabolism*
  • Rabbits
  • Secretin / blood


  • Bicarbonates
  • Fat Emulsions, Intravenous
  • Oleic Acids
  • Propionates
  • Secretin
  • Oleic Acid