Positive and negative regulators of the Saccharomyces cerevisiae 'PHO system' participate in several cell functions

FEMS Microbiol Lett. 1993 Apr 15;108(3):333-9. doi: 10.1111/j.1574-6968.1993.tb06124.x.


The yeast PHO regulatory genes are indispensable for the transcriptional control of structural genes involved in phosphate metabolism. Some of these regulatory genes have pleiotropic functions apparently independent of phosphate metabolism. Our results point to an involvement in the life cycle of the PHO2 activator and the PHO85-negative factor and to a reduced ability of the negative pho regulatory mutants, pho80 and pho85, to grow on non-fermentable carbon sources.

MeSH terms

  • Carbon / metabolism
  • Cyclin-Dependent Kinases*
  • Fungal Proteins / genetics*
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Genes, Fungal*
  • Genes, Homeobox
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae Proteins*
  • Transcription, Genetic


  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins
  • Carbon
  • Cyclin-Dependent Kinases
  • PHO85 protein, S cerevisiae