Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase

Neurosci Lett. 1993 Apr 2;152(1-2):33-6. doi: 10.1016/0304-3940(93)90476-2.


We have examined whether D-amino acid oxidase (DAO) regulates free D-serine content using mutant ddY/DAO- mice lacking DAO activity. We find that the content of D-serine in the serum and cerebellum of mutant mice is much higher than that of normal mice, whereas a slight but significant difference in the cerebral D-serine level is observed between the two strains. These results suggest that, although DAO may participate in the catabolism of D-serine in the cerebellum and periphery, there appears to be other mechanisms for catabolism of endogenous D-serine in the brain.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine / analysis*
  • Alanine / blood
  • Animals
  • Aspartic Acid / analysis*
  • Aspartic Acid / blood
  • Brain Chemistry*
  • Cerebellum / chemistry
  • D-Amino-Acid Oxidase / deficiency*
  • D-Amino-Acid Oxidase / genetics
  • D-Amino-Acid Oxidase / physiology
  • Male
  • Mice
  • Mice, Mutant Strains / metabolism*
  • Serine / analysis*
  • Serine / blood
  • Stereoisomerism


  • Aspartic Acid
  • Serine
  • D-Amino-Acid Oxidase
  • Alanine