Expression of intercellular adhesion molecule-1 on transitional cell cancer. Possible significance in immunity against tumor cells

Am J Pathol. 1993 Jul;143(1):191-8.

Abstract

Immunohistochemical examination demonstrated expression of intercellular adhesion molecule-1 (ICAM-1) on 17 of 44 transitional cell cancers (TCCs) but not on normal transitional cells. ICAM-1 was frequently expressed in higher stage tumors, especially in those with abundant immune cells scattered within tumor. Analysis of infiltrating immune cells showed that they were composed mainly of T lymphocytes and a smaller number of macrophages bearing the lymphocyte function-associated antigen-1 (LFA-1). Expression of ICAM-1 on transitional cell cancer cell lines was augmented by in vitro treatment with interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 beta. Furthermore, Northern blot analysis revealed higher quantities of a 3.3-kb RNA in T24 cells exposed to interferon-gamma or tumor necrosis factor-alpha. These results suggest that the expression of ICAM-1 on transitional cell cancers might be modified by cytokines produced by infiltrating immune cells, which might facilitate immune responses against cancer cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antigens, Surface / analysis
  • B-Lymphocytes / cytology
  • Carcinoma, Transitional Cell / chemistry*
  • Cell Adhesion Molecules / analysis*
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / immunology
  • Cytokines / pharmacology
  • Female
  • Humans
  • Intercellular Adhesion Molecule-1
  • Interferon-gamma / pharmacology
  • Lymphocytes, Tumor-Infiltrating / chemistry
  • Male
  • Middle Aged
  • Neoplasm Invasiveness / immunology
  • RNA, Messenger / analysis
  • T-Lymphocytes / cytology
  • Tumor Cells, Cultured / chemistry
  • Tumor Necrosis Factor-alpha / pharmacology
  • Ureteral Neoplasms / chemistry
  • Urinary Bladder Neoplasms / chemistry

Substances

  • Antigens, Surface
  • Cell Adhesion Molecules
  • Cytokines
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • Intercellular Adhesion Molecule-1
  • Interferon-gamma