Smoking, CD45R0+ (memory), and CD45RA+ (naive) CD4+ T cells

Am Rev Respir Dis. 1993 Jul;148(1):237-40. doi: 10.1164/ajrccm/148.1.237.

Abstract

The relationship between smoking and percentages and counts of T-cell subsets, in particular CD45R0+ (memory) and CD45RA+ (naive) CD4+ lymphocytes, have been assessed in a sample of 311 middle-aged men working in the Paris area. Percentages of lymphocytes with the phenotypes CD4+, CD8+, CD4+CD45R0+, and CD4+CD45RA+ were determined using double immunofluorescence labeling. All cell counts, including CD4+CD45R0+, and CD4+CD45RA+ lymphocytes increased significantly with tobacco consumption, as did the percentages of lymphocytes with the CD4+CD45R0+ and CD4+ phenotypes. The increase in the percentage of lymphocytes with the CD4+CD45RA+ phenotype, although not significant, was similar to that observed in the percentage of CD4+CD45R0+ lymphocytes. When the proportions of CD4+ cells with the CD45R0+ or the CD45RA+ phenotype were considered, no specific modification of any of these two sub-populations was observed: the effect of smoking on memory and naive Cd4+ lymphocytes seemed to be equivalent.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Analysis of Variance
  • CD4-Positive T-Lymphocytes / immunology*
  • Humans
  • Immunologic Techniques
  • Leukocyte Common Antigens / blood*
  • Leukocyte Count
  • Male
  • Middle Aged
  • Paris / epidemiology
  • Phenotype
  • Smoking / epidemiology
  • Smoking / immunology*
  • T-Lymphocyte Subsets / immunology*

Substances

  • Leukocyte Common Antigens