Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue

Lancet. 1993 Aug 7;342(8867):337-8. doi: 10.1016/0140-6736(93)91475-2.


It is not clear whether the ophthalmopathy present in Graves' disease is related to autoimmune reactions to common thyroid/orbit components or is due to specific ocular antigens unrelated to the thyroid. In Graves' disease, serum antibodies to the thyrotropin receptor (TSH-R) can stimulate thyroid function, but no link between the TSH-R and ocular tissues has been found. We have shown, by polymerase chain reaction amplification of specific cDNA, that mature TSH-R mRNA is expressed in the retro-orbital tissue of both healthy subjects and patients with Graves' disease. Of other tissues and cells tested (fibroblasts, lymphocytes, muscle, and thyroid), only thyroid tissue expressed the TSH-R mRNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Probes
  • Graves Disease / genetics*
  • Humans
  • Molecular Sequence Data
  • Orbit / chemistry*
  • Polymerase Chain Reaction
  • RNA, Messenger / isolation & purification*
  • Receptors, Thyrotropin / chemistry*


  • DNA Probes
  • RNA, Messenger
  • Receptors, Thyrotropin