Selective differentiation of CD4+ T helper cell subsets

Curr Opin Immunol. 1993 Jun;5(3):391-7. doi: 10.1016/0952-7915(93)90058-z.


During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4 T helper cell subsets. These have been driven, in part, by the realization that signals (cytokines) from the innate immune response are critical in T cell subset differentiation. In addition, several studies have also elucidated how the antigen-presenting cell, the antigenic epitope and the antigen concentration may contribute to the selective development of a particular T helper cell subset.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • CD4-Positive T-Lymphocytes / cytology*
  • CD4-Positive T-Lymphocytes / immunology
  • Cell Differentiation
  • Cytokines / physiology
  • Humans
  • Infections / immunology
  • Mice
  • Mice, Inbred BALB C / immunology
  • Mice, SCID / immunology
  • Mice, Transgenic
  • Models, Biological
  • Receptors, Antigen, T-Cell / immunology
  • Signal Transduction


  • Cytokines
  • Receptors, Antigen, T-Cell