Vitamin E treatment of tardive dyskinesia

Am J Psychiatry. 1993 Sep;150(9):1405-7. doi: 10.1176/ajp.150.9.1405.


Objective: The authors studied the effects of vitamin E treatment of tardive dyskinesia; earlier studies have produced contradictory results.

Method: Twenty-eight patients with tardive dyskinesia were treated in a double-blind, parallel-group comparison study of 8-12 weeks of treatment with vitamin E (1600 IU/day) or matching placebo capsules.

Results: The Abnormal Involuntary Movement Scale scores of the patients treated with vitamin E improved significantly compared to the scores of the patients given placebo.

Conclusions: These results support earlier findings of the efficacy of vitamin E in treating tardive dyskinesia.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Ambulatory Care
  • Antipsychotic Agents / adverse effects
  • Double-Blind Method
  • Dyskinesia, Drug-Induced / drug therapy*
  • Dyskinesia, Drug-Induced / etiology
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Placebos
  • Schizophrenia / drug therapy
  • Vitamin E / therapeutic use*


  • Antipsychotic Agents
  • Placebos
  • Vitamin E