Correction of Duncan's syndrome by allogeneic bone marrow transplantation

Lancet. 1993 Sep 4;342(8871):587-8. doi: 10.1016/0140-6736(93)91413-g.


Duncan's syndrome (X-linked lymphoproliferative disorder) is a fatal immunodeficiency syndrome of unknown aetiology and without cure. We show that allogeneic bone marrow transplantation can correct the lethal immune deficits in a patient with this syndrome. We suggest that the primary abnormality in Duncan's syndrome is in bone-marrow derived cells.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bone Marrow Transplantation*
  • Child
  • Humans
  • Lymphoproliferative Disorders / surgery*
  • Male
  • Transplantation, Homologous