Apolipoprotein E epsilon 4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

Lancet. 1993 Sep 18;342(8873):710-1. doi: 10.1016/0140-6736(93)91709-u.


The frequency of the allele for apolipoprotein E type 4 (epsilon 4) is increased in late-onset familial and sporadic Alzheimer's disease (AD). We have examined epsilon 4 frequencies in four distinct, normal, elderly control groups and, most importantly, in patients with amyloid-forming diseases whose epsilon 4 distributions were not previously known (Creutzfeldt-Jakob disease, familial amyloidotic polyneuropathy, Down's syndrome). There were no differences between any of these controls and published control series, cementing the relevance of epsilon 4 for late-onset AD. The increase in late-onset AD was confirmed in two new series.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Alleles*
  • Alzheimer Disease / genetics*
  • Amyloidosis / genetics
  • Apolipoprotein E4
  • Apolipoproteins E / genetics*
  • Creutzfeldt-Jakob Syndrome / genetics
  • Down Syndrome / genetics
  • Gene Frequency
  • Hereditary Sensory and Autonomic Neuropathies / genetics
  • Humans


  • Apolipoprotein E4
  • Apolipoproteins E