Proteins with SH2 and SH3 domains couple receptor tyrosine kinases to intracellular signalling pathways

Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29;340(1293):279-85. doi: 10.1098/rstb.1993.0069.


The targets of receptor protein-tyrosine kinases are characterized by Src homology 2 (SH2) domains, that mediate specific interactions with receptor autophosphorylation sites. SH2-mediated interactions are important for the activation of biochemical signalling pathways in cells stimulated with growth factors. A distinct protein module, the SH3 domain, is frequently found in polypeptides that contain SH2 domains, and is also implicated in controlling protein-protein interactions in signal transduction. Evidence suggesting that SH2 and SH3 domains act synergistically in stimulation of the Ras pathway is discussed.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Caenorhabditis elegans / physiology
  • Drosophila / physiology
  • Mammals / physiology
  • Molecular Sequence Data
  • Phosphorylation
  • Protein-Tyrosine Kinases / metabolism*
  • Receptors, Cell Surface / metabolism*
  • Sequence Homology, Amino Acid
  • Signal Transduction*


  • Receptors, Cell Surface
  • Protein-Tyrosine Kinases