The CYP1A1 gene and cancer susceptibility

Crit Rev Oncol Hematol. 1993 Feb;14(1):77-87. doi: 10.1016/1040-8428(93)90007-q.


A close correlation between cigarette smoking associated lung cancer incidence and an Msp I restriction fragment length polymorphism (RFLP) of the human P-450 1A1 (CYP1A1) gene was found in a Japanese population in terms of genotype frequency and cigarette dose. A Val/Ile codon difference in the primary structure of the CYP1A1 protein (Val-, Ile-type) was in linkage disequilibrium with the Msp I RFLP. A synergistic increase in susceptibility to lung cancer was found when combining genotyping of CYP1A1 and the Mu-class of glutathione S-transferase (GST1). Interindividual variability in the genetic make-up of carcinogen metabolizing enzymes may thus be a key host factor to explain the differences in susceptibility to chemical carcinogenesis among individuals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cytochrome P-450 Enzyme System / genetics*
  • Genetic Linkage
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Incidence
  • Lung Neoplasms / etiology
  • Lung Neoplasms / genetics
  • Neoplasms / epidemiology
  • Neoplasms / genetics*
  • Polymorphism, Restriction Fragment Length
  • Smoking / adverse effects


  • Cytochrome P-450 Enzyme System