Dopamine D2 receptor alteration in patients with periodic movements in sleep (nocturnal myoclonus)

J Neural Transm Gen Sect. 1993;93(1):71-4. doi: 10.1007/BF01244940.


Periodic movements in sleep (PMS) can cause severe sleep disturbances. We investigated the central dopamine D2 receptor density in patients with PMS with 123I-IBZM and single photon emission tomography (SPET). In PMS there was a lower 123I-IBZM binding in the basal ganglia compared to the control group. The results indicate a loss of central D2 receptors in PMS.

MeSH terms

  • Adult
  • Aged
  • Corpus Striatum / diagnostic imaging
  • Dopamine Agents / therapeutic use
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myoclonus / diagnostic imaging
  • Myoclonus / drug therapy
  • Myoclonus / metabolism*
  • Periodicity*
  • Receptors, Dopamine D2 / metabolism*
  • Sleep Wake Disorders / diagnostic imaging
  • Sleep Wake Disorders / drug therapy
  • Sleep Wake Disorders / metabolism*
  • Tomography, Emission-Computed, Single-Photon


  • Dopamine Agents
  • Receptors, Dopamine D2