Lysyl oxidase copper-talon complex: a model

Biochim Biophys Acta. 1993 Sep 3;1202(1):7-12. doi: 10.1016/0167-4838(93)90056-w.

Abstract

The translated primary amino-acid sequences from human genomic and human, rat and mouse lysyl oxidase cDNAs were subjected to computer comparison. This revealed a highly-conserved primary structure and similar computer-predicted secondary structures. A prototypical lysyl oxidase structural model was reconciled with the known physical, chemical and biological properties. Analysis of the post-translationally-modified and proteolytically-processed mature enzyme model revealed a copper coordination complex that may be contained as part of the active site. This integral copper coordination complex resembles a talon. The proposed model should facilitate the elucidation of these and other structural and functional relationships within the lysyl oxidase molecule.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Hydroxycoumarins / chemistry*
  • Amino Acid Sequence
  • Animals
  • Copper / chemistry*
  • Humans
  • Mice
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Structure, Secondary*
  • Protein-Lysine 6-Oxidase / chemistry*
  • Protein-Lysine 6-Oxidase / genetics
  • Rats
  • Sequence Alignment
  • Software

Substances

  • 4-Hydroxycoumarins
  • Copper
  • bromfenacoum
  • Protein-Lysine 6-Oxidase