Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences

Mamm Genome. 1993;4(8):435-9. doi: 10.1007/BF00296817.

Abstract

Simple-sequence tandem repeat sequences in the 3' UTR of interleukin 5 (IL5)-receptor gene of human and mouse are polymorphic in their length among humans and different strains of mice. In 20 different human Epstein-Barr virus (EBV)-transformed cell lines, six alleles of IL5R could be distinguished. In the mouse, three different alleles are found. With the human-specific IL5R tandem repeat marker in human-rodent somatic cell hybrids, the IL5R gene was mapped to human Chromosome (Chr) 3 p25-p26. With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus.

MeSH terms

  • Animals
  • Base Sequence
  • Chromosome Mapping*
  • Chromosomes, Human, Pair 3*
  • Conserved Sequence
  • DNA, Recombinant
  • Genetic Markers
  • Humans
  • Hybrid Cells
  • Interleukin-4 / genetics*
  • Mice / genetics*
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Mice, Inbred DBA
  • Molecular Sequence Data
  • Polymorphism, Restriction Fragment Length
  • Proto-Oncogenes / genetics*
  • Receptors, Immunologic / genetics*
  • Receptors, Interleukin*
  • Receptors, Interleukin-5
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Homology, Nucleic Acid

Substances

  • DNA, Recombinant
  • Genetic Markers
  • Receptors, Immunologic
  • Receptors, Interleukin
  • Receptors, Interleukin-5
  • Interleukin-4