Dopamine D3 receptor: basic and clinical aspects

Clin Neuropharmacol. 1993 Aug;16(4):295-314. doi: 10.1097/00002826-199308000-00002.


The recently discovered dopamine D3 receptor can be considered as a D2-like receptor: it is encoded by a gene comprising several introns; it is both an autoreceptor and a postsynaptic receptor, well recognized by antipsychotics. It differs, however, from the D2 receptor by a much more discrete expression, mostly in few limbic brain areas, e.g. shell of nucleus accumbens, islands of Calleja, and a considerably higher affinity for dopamine. Two association studies preliminarily suggest that the homozygotes for a D3 receptor gene polymorphism display twofold higher risk of schizophrenia, whereas several linkage studies led to inconclusive results.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antipsychotic Agents / pharmacology
  • Humans
  • Molecular Sequence Data
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / genetics
  • Receptors, Dopamine / physiology*
  • Receptors, Dopamine D2*
  • Receptors, Dopamine D3


  • Antipsychotic Agents
  • DRD3 protein, human
  • Receptors, Dopamine
  • Receptors, Dopamine D2
  • Receptors, Dopamine D3