Combination drug therapy with calcium-channel blockers in the treatment of systemic hypertension

J Clin Pharmacol. 1993 Aug;33(8):752-5. doi: 10.1002/j.1552-4604.1993.tb05619.x.


Calcium-channel blockers have been shown to be both safe and effective for treatment of patients with systemic hypertension. These drugs reduce peripheral vascular resistance predominantly by the inhibition of transmembrane calcium ion fluxes in vascular smooth muscle, and by this mechanism can reduce elevated blood pressure. To maximize blood pressure lowering efficacy in patients, calcium-channel blockers have also been used in combination with other antihypertensive treatments that have included diuretics, beta-adrenergic blockers, and angiotensin-converting enzyme inhibitors.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Angina Pectoris / drug therapy
  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Blood Pressure / drug effects
  • Calcium Channel Blockers / pharmacology
  • Calcium Channel Blockers / therapeutic use*
  • Drug Therapy, Combination
  • Humans
  • Hypertension / drug therapy*
  • Myocardial Ischemia / prevention & control
  • Vascular Resistance / drug effects


  • Adrenergic beta-Antagonists
  • Angiotensin-Converting Enzyme Inhibitors
  • Calcium Channel Blockers