A modified polyriboinosinic-polyribocytidylic acid complex that induces interferon in primates

J Infect Dis. 1975 Oct;132(4):434-9. doi: 10.1093/infdis/132.4.434.


A comlex of polyriboinosinic-polyribocytidylic acid (poly I-poly C) with poly-L-lysine and carboxymethylcellulose has been prepared. This complex is five to 10 times as resistant to hydrolysis by primate serum as the parent poly I-poly C. It has a thermal denaturation temperature about 40 C higher than that of poly I-poly C. The complex induces significant levels of serum interferon in monkeys and chimpanzees under conditions in which poly I-poly C itself induces no interferon.

MeSH terms

  • Animals
  • Carboxymethylcellulose Sodium / pharmacology
  • Female
  • Haplorhini
  • Hot Temperature
  • Humans
  • Hydrolysis
  • Interferons / biosynthesis*
  • Interferons / cerebrospinal fluid
  • Kinetics
  • Macaca / blood*
  • Macaca mulatta / blood*
  • Mice
  • Molecular Weight
  • Pan troglodytes / blood*
  • Poly I-C / pharmacology*
  • Polylysine / pharmacology


  • Polylysine
  • Interferons
  • Carboxymethylcellulose Sodium
  • Poly I-C