Insulin-like growth factor-I comparisons in healthy twin children

J Clin Endocrinol Metab. 1994 Feb;78(2):310-2. doi: 10.1210/jcem.78.2.8106617.

Abstract

Insulin-like growth factor-I (IGF-I) levels in plasma were measured in healthy twin children. The within-pair correlation for 43 monozygotic pairs was r = 0.91 (P < or = 0.0001), an association significantly higher than that for same sex dizygotic pairs (r = 0.40; P < or = 0.06). The high correlation for monozygotic twins indicated a marked genetic influence on IGF-I levels. After correction for age and sex, the correlation between IGF-I level and height was r = 0.38 (P < or = 0.0001). These findings provide clear evidence that IGF-I levels correlate with height, a growth characteristic known to be genetically controlled.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / blood
  • Aging / physiology
  • Biomarkers / blood
  • Body Height / physiology
  • Child
  • Child, Preschool
  • Family Health
  • Female
  • Humans
  • Insulin-Like Growth Factor I / analysis*
  • Insulin-Like Growth Factor I / genetics
  • Insulin-Like Growth Factor I / physiology
  • Male
  • Phenotype
  • Twins, Dizygotic*
  • Twins, Monozygotic*

Substances

  • Biomarkers
  • Insulin-Like Growth Factor I