How B and T cells talk to each other

Nature. 1994 Feb 3;367(6462):425-8. doi: 10.1038/367425a0.


The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact have only recently become apparent.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology
  • B-Lymphocytes / physiology*
  • Cell Adhesion Molecules / physiology
  • Cell Communication / physiology
  • Humans
  • Lymphocyte Activation / physiology
  • Receptors, Antigen, B-Cell / physiology
  • T-Lymphocytes / physiology*


  • Antigens, CD
  • Cell Adhesion Molecules
  • Receptors, Antigen, B-Cell