Migration of glia along photoreceptor axons in the developing Drosophila eye

Neuron. 1994 Feb;12(2):423-31. doi: 10.1016/0896-6273(94)90282-8.


We have identified a set of retinal basal glia, designated RBG cells, in the axon layer of the developing Drosophila eye disc. In vivo pulse labeling with bromodeoxyuridine shows that these cells originate in the optic stalk and migrate into the disc. In mutants lacking photoreceptor axons, RBG cells accumulate in the optic stalk, but do not invade the disc. The association of RBG cells with photoreceptor axons, their origin in the optic stalk, and their migration into the retina are in common with the behavior of astrocytes in the developing mammalian retina.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Axons / physiology*
  • Axons / ultrastructure
  • Cell Movement
  • Drosophila / genetics
  • Drosophila / physiology*
  • Enhancer Elements, Genetic
  • Eye / growth & development*
  • Eye / innervation*
  • Mutation
  • Neuroglia / physiology*
  • Optic Disk / ultrastructure
  • Photoreceptor Cells, Invertebrate / physiology*
  • Photoreceptor Cells, Invertebrate / ultrastructure
  • Retina / cytology*