Effects of neuromedin U-8 on the rat pituitary-adrenocortical axis

In Vivo. 1993 Sep-Oct;7(5):419-22.


A single subcutaneous injection of 6 micrograms/100 g body wt. of neuromedin U-8 (NMU8) resulted in a transient increase in ACTH blood concentration (between 3 and 12 h) and a sustained (24 h) elevation of plasma corticosterone (B) concentration (PBC). After a 2-day subcutaneous administration of NMU8 (2 or 6 micrograms/100 g/day) blood ACTH level remained unchanged, but PBC was notably raised. Adrenal glands were atrophic, due to a marked loss of parenchymal cells, but in spite of this their basal in vitro output of B did not differ from that of control glands. These findings indicate that NMU8 stimulates pituitary-adrenocortical axis in rats. Furthermore, they suggest that, in addition to the enhancement in ACTH release, other mechanism(s) must be involved in the adrenocortical secretagogue effect of NMU8.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Glands / drug effects
  • Adrenal Glands / pathology
  • Adrenocorticotropic Hormone / metabolism*
  • Animals
  • Atrophy
  • Cell Count / drug effects
  • Corticosterone / metabolism*
  • Female
  • Injections, Subcutaneous
  • Neuropeptides / pharmacology*
  • Organ Size / drug effects
  • Pituitary Gland / drug effects
  • Pituitary Gland / pathology
  • Pituitary-Adrenal System / drug effects*
  • Pituitary-Adrenal System / metabolism
  • Rats


  • Neuropeptides
  • Adrenocorticotropic Hormone
  • neuromedin U 8
  • Corticosterone