A comparative assessment of amlodipine and felodipine ER: pharmacokinetic and pharmacodynamic indices

Eur J Clin Pharmacol. 1993;45(5):425-30. doi: 10.1007/BF00315513.


This study investigated potential therapeutic differences between Amlodipine 5 mg and Felodipine ER 10 mg in 12 normotensive/borderline hypertensive subjects by comparison of the plasma drug concentration-time profiles and the blood pressure and heart rate responses. There was significantly less trough-to-peak variability in plasma drug concentrations with amlodipine with a ratio of 67%, compared to 37% for felodipine. Correspondingly there was less variability with amlodipine in the blood pressure reductions across the dosage interval. Overall, amlodipine displayed a more consistent hypotensive effect across 24 hours and lower blood pressure values at trough, i.e. 24 hours post-dose.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Amlodipine / pharmacokinetics*
  • Amlodipine / pharmacology
  • Blood Pressure / drug effects*
  • Delayed-Action Preparations
  • Felodipine / pharmacokinetics*
  • Felodipine / pharmacology
  • Female
  • Heart Rate / drug effects*
  • Humans
  • Male
  • Middle Aged


  • Delayed-Action Preparations
  • Amlodipine
  • Felodipine