Influence of gender in acute and long-term cardiac mortality after a first myocardial infarction. REGICOR Investigators

J Clin Epidemiol. 1994 Feb;47(2):111-8. doi: 10.1016/0895-4356(94)90016-7.


The effect of gender and other clinical variables on short-term and long-term cardiac mortality after a first transmural myocardial infarction (MI) was assessed in a population-based hospital register. A cohort of 1216 consecutive patients (1023 men and 193 women), 25-74 years old admitted to the only reference hospital with a coronary care unit at Girona, Northeastern Spain, were recruited for 1978 to 1988 and followed-up for a mean period of almost 5 years (3-12 years). Compared with men, women had a relative risk (RR) of 1.56 (95% confidence interval (CI) of 0.99-2.48) of dying in the acute phase of MI after adjusting for age, MI location, presence of severe arrhythmias, diabetes and hypertension. However, when additionally adjusting for severity (Killip class), women presented a RR of 1.11. Age and hypertension were independent risk factors for acute mortality. Women surviving the acute period of MI showed a RR of 1.37 (CI 0.97-1.92) for long-term mortality, that was only slightly modified by Killip class during hospital stay (RR = 1.27). Age and diabetes were independent risk factors for long term mortality. It is concluded that women have a 56% excess risk for early mortality after a first transmural MI than men mainly explained by a higher severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Angina Pectoris / complications
  • Arrhythmias, Cardiac / complications
  • Cohort Studies
  • Confidence Intervals
  • Diabetes Complications
  • Electrocardiography
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / complications
  • Male
  • Middle Aged
  • Myocardial Infarction / complications
  • Myocardial Infarction / mortality*
  • Proportional Hazards Models
  • Recurrence
  • Regression Analysis
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • Spain / epidemiology
  • Survival Analysis