Surveillance scanning of children with medulloblastoma

N Engl J Med. 1994 Mar 31;330(13):892-5. doi: 10.1056/NEJM199403313301303.


Background: The standard follow-up care for children with medulloblastoma includes regular clinical evaluations and surveillance scanning of the central nervous system with computed tomography or magnetic resonance imaging. The evaluations and scanning assess the response of the tumor to treatment, detect any recurrence of disease, and monitor any complications of treatment. We compared the effectiveness of a periodic history taking and physical examination with that of surveillance scanning in detecting recurrent tumors.

Methods: We reviewed the medical records, including 794 scanning reports or scans, of 86 children with posterior fossa medulloblastoma who were followed regularly between 1980 and 1991. Recurrent tumors were classified as symptomatic if neuroimaging studies had been prompted by clinical symptoms or signs and as radiographic if the tumor had been detected by imaging in an asymptomatic patient.

Results: Twenty-three of the 86 children (27 percent) had a recurrence of tumor. Four recurrences (17 percent) were detected on scanning only, and 19 (83 percent) were associated with symptoms arising a median of four months after the previous scan. The median and range of survival after a recurrence of the tumor were 5 months and < 1 to 38 months, respectively, for a symptomatic recurrence and 20 months and 10 to 32 months, respectively, for a radiographic recurrence (P = 0.03). No patient survived after a recurrence. The longer survival of patients with recurrent tumors detected by scanning most likely reflects the small number of patients and lead-time and length biases associated with screening.

Conclusions: Among children with medulloblastoma, surveillance scanning is of little clinical value. Scanning detected a minority of recurrences, and no patient who had a recurrence survived.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Central Nervous System Neoplasms / diagnosis
  • Central Nervous System Neoplasms / secondary
  • Cerebellar Neoplasms / diagnosis*
  • Cerebellar Neoplasms / mortality
  • Child
  • Child, Preschool
  • Cranial Fossa, Posterior
  • Female
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Medulloblastoma / diagnosis*
  • Medulloblastoma / mortality
  • Medulloblastoma / secondary
  • Neoplasm Recurrence, Local / diagnosis*
  • Neoplasm Recurrence, Local / mortality
  • Tomography, X-Ray Computed