Neuropeptide Y potentiates via Y2-receptors the inhibitory effect of noradrenaline in rat locus coeruleus neurones

Naunyn Schmiedebergs Arch Pharmacol. 1993 Nov;348(5):546-8. doi: 10.1007/BF00173217.

Abstract

Intracellular recordings were carried out in a pontine slice preparation of the rat brain containing the locus coeruleus (LC). Pressure application of noradrenaline with various pulse durations inhibited the spontaneous frequency of action potentials and hyperpolarized the membrane. Neuropeptide Y (NPY), its C-terminal fragment NPY (16-36) and peptide YY (PYY), at a concentration of 0.1 mumol/l all, potentiated the effect of noradrenaline, while [Leu31, Pro34]NPY (0.1 mumol/l) was inactive. These results are compatible with the presence of Y2-type NPY-receptors at the cell somata of LC neurones.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Synergism
  • Electrophysiology
  • Gastrointestinal Hormones / pharmacology
  • In Vitro Techniques
  • Locus Coeruleus / cytology
  • Locus Coeruleus / drug effects
  • Locus Coeruleus / metabolism*
  • Membrane Potentials / drug effects
  • Neurons / drug effects
  • Neurons / metabolism*
  • Neuropeptide Y / analogs & derivatives
  • Neuropeptide Y / pharmacology*
  • Norepinephrine / pharmacology*
  • Peptide YY
  • Peptides / pharmacology
  • Pons / drug effects
  • Pons / metabolism
  • Rats
  • Receptors, Adrenergic, alpha-2 / drug effects
  • Receptors, Neuropeptide / antagonists & inhibitors*

Substances

  • Gastrointestinal Hormones
  • Neuropeptide Y
  • Peptides
  • Receptors, Adrenergic, alpha-2
  • Receptors, Neuropeptide
  • Peptide YY
  • Norepinephrine