Cerebrospinal fluid-intracranial volume ratio measurements in patients with HIV infection: CLASS image analysis technique

Radiology. 1994 Mar;190(3):879-86. doi: 10.1148/radiology.190.3.8115644.


Purpose: To prospectively study the cerebrospinal fluid volume-total intracranial volume ratio (CSF/ICV) in human immunodeficiency virus (HIV)-infected patients at various stages of disease.

Materials and methods: A total of 258 volume measurements were obtained with use of a 1.5-T magnetic resonance (MR) imager and the cluster localized automated spherical segmentation technique (which reduces two-dimensional pixel data from dual spin-echo MR images to a one-dimensional histogram) in 69 control subjects and 189 HIV-infected patients.

Results: The CSF/ICV was statistically significantly increased in patients with late-stage (Centers for Disease Control and Prevention group IV) acquired immunodeficiency syndrome (AIDS) (0.16 +/- 0.05 [standard deviation]) compared with seronegative control subjects (0.12 +/- 0.03) and patients without symptoms (0.13 +/- 0.03).

Conclusion: No substantial change in CSF/ICV occurs until development of late-stage AIDS.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / cerebrospinal fluid
  • Acquired Immunodeficiency Syndrome / diagnosis*
  • Acquired Immunodeficiency Syndrome / epidemiology
  • Adult
  • Atrophy
  • Brain / pathology*
  • HIV Seronegativity
  • HIV Seropositivity
  • Homosexuality
  • Humans
  • Image Processing, Computer-Assisted*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Models, Structural
  • Prospective Studies
  • Risk Factors