Clearance and distribution of ciprofloxacin after intravitreal injection

Retina. 1993;13(4):326-30. doi: 10.1097/00006982-199313040-00010.

Abstract

This study was designed to determine the drug concentration and clearance after intravitreal injection of ciprofloxacin. Ciprofloxacin (100 micrograms/0.1 cc) was injected into the vitreous of normal eyes and into eyes that had undergone lensectomy and vitrectomy. Drug concentration was determined using high-pressure liquid chromatography analysis 0.5, 2, 4, and 12 hours after injection. In normal eyes, the elimination half life was 2.2 hours with a distribution volume of 1.2 ml. In aphakic vitrectomized eyes, the half life was 1 hour and the distribution volume was 1.4 ml. The majority of the drug appears to leave via a transretinal route, but clearance was not inhibited by probenecid. Because of the relatively short half life, intravitreal administration of ciprofloxacin for the treatment of endophthalmitis would provide only short-term therapy and would need to be supplemented by other forms of treatment.

MeSH terms

  • Animals
  • Aqueous Humor / metabolism*
  • Cataract Extraction
  • Chromatography, High Pressure Liquid
  • Ciprofloxacin / pharmacokinetics*
  • Half-Life
  • Injections
  • Rabbits
  • Vitrectomy
  • Vitreous Body / metabolism*

Substances

  • Ciprofloxacin