Guidelines for the Safe Administration of Inhaled Nitric Oxide

Arch Dis Child Fetal Neonatal Ed. 1994 Jan;70(1):F47-9. doi: 10.1136/fn.70.1.f47.


Inhaled nitric oxide (NO) is a selective pulmonary vasodilator, potentially useful in the treatment of pulmonary hypertension and ventilation-perfusion mismatch. High doses of inhaled NO and its oxidative product nitrogen dioxide (NO2) may cause acute lung injury. Using a standard infant ventilator, ventilator circuit and test lung, an administration and monitoring strategy has been defined for inhaled NO and these observations validated in eight ventilated infants. In 90% oxygen, doses of inhaled NO > or = 80 parts per million may result in toxic NO2 concentrations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Inhalation
  • Drug Administration Schedule
  • Humans
  • Hypertension, Pulmonary / drug therapy
  • Infant
  • Models, Biological*
  • Nitric Oxide / administration & dosage*
  • Nitric Oxide / adverse effects
  • Nitric Oxide / metabolism
  • Nitrogen Dioxide / metabolism
  • Respiration, Artificial / standards*


  • Nitric Oxide
  • Nitrogen Dioxide