Varying thrombolytic administration rates in elderly patients with acute myocardial infarction

Br J Clin Pract. Nov-Dec 1993;47(6):305-7.

Abstract

Receipt of thrombolytic therapy in patients aged 75 or over with proven acute myocardial infarction admitted initially to either the coronary care unit (CCU) or a geriatric medical ward (GMW) was studied retrospectively in a hospital administering thrombolysis only in the CCU. Mean age and age distribution of patients admitted to each unit initially showed no significant difference. Of 50 patients admitted directly to the CCU, 28 (56%) received thrombolysis, compared with 13 of 50 (26%) GMW admissions (P < 0.02). Of 37 GMW admissions, 14 (38%) failed to receive thrombolysis without documented contraindication compared with 2 of 22 (9%) CCU admissions (P < 0.05). Aspirin was administered in 39 (78%) CCU and 31 (62%) GMW admissions (P < 0.05). Non-administration of aspirin without apparent contraindication occurred in 3 of 11 (27%) compared with 8 of 19 (42%) GMW admissions (NS). Elderly patients thus failed to receive thrombolytic therapy as a result of initial admission to a unit unable to administer this treatment.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Aspirin / administration & dosage
  • Cardiac Care Facilities
  • Contraindications
  • Female
  • Humans
  • Male
  • Myocardial Infarction / drug therapy*
  • Retrospective Studies
  • Streptokinase / administration & dosage
  • Thrombolytic Therapy / statistics & numerical data*

Substances

  • Streptokinase
  • Aspirin