Deletion of highly conserved C-terminal sequences in the Kv1 K+ channel sub-family does not prevent expression of currents with wild-type characteristics

FEBS Lett. 1994 Feb 28;340(1-2):104-8. doi: 10.1016/0014-5793(94)80181-9.


The C-terminal regions of Kv1 K+ channels show little conservation between isoforms except for the last four C-terminal residues, (E/L)TDV, which are well conserved from Drosophila to man. Deletions of the 4, 16, and 57 C-terminal residues of the human Kv1.5 channel did not affect whole cell current amplitude, midpoint of activation, degree of inactivation, or activation kinetics following expression in mouse L-cells. Similar results were obtained with the rat Kv1.1 channel. Therefore, the conserved (E/L)TDV motif, and most of the C-terminal amino acids, are not required for Kv1 channel expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Conserved Sequence*
  • Drosophila
  • Humans
  • Membrane Potentials
  • Molecular Sequence Data
  • Oligodeoxyribonucleotides
  • Potassium Channels / genetics*
  • Potassium Channels / physiology
  • Rats
  • Sequence Deletion*
  • Sequence Homology, Amino Acid


  • Oligodeoxyribonucleotides
  • Potassium Channels

Associated data

  • GENBANK/M60451