Genes for members of the GATA-binding protein family (GATA-GT1 and GATA-GT2) together with H+/K(+)-ATPase are specifically transcribed in gastric parietal cells

FEBS Lett. 1994 Feb 28;340(1-2):117-20. doi: 10.1016/0014-5793(94)80184-3.

Abstract

mRNAs for novel DNA-binding proteins (GATA-GT1 and GATA-GT2) recognizing the (G/C)PuPu(G/C)NGAT(A/T)PuPy sequence and H+/K(+)-ATPase (proton pump) alpha subunit were detected in parietal cells of the rat gastric body mucosa by in situ hybridization. These results suggest that GATA-GT1 and GATA-GT2 together with H+/K(+)-ATPase are transcribed specifically in gastric parietal cells and that the two DNA-binding proteins may have important roles in cell specific gene regulation. Furthermore, we could detect parietal cells in different states of gene expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • DNA-Binding Proteins / genetics*
  • GATA4 Transcription Factor
  • GATA6 Transcription Factor
  • In Situ Hybridization
  • Multigene Family*
  • Parietal Cells, Gastric / enzymology
  • Parietal Cells, Gastric / metabolism*
  • Rats
  • Rats, Wistar
  • Sodium-Potassium-Exchanging ATPase / genetics*
  • Transcription Factors / genetics*
  • Transcription, Genetic*
  • Zinc Fingers

Substances

  • DNA-Binding Proteins
  • GATA4 Transcription Factor
  • GATA6 Transcription Factor
  • Gata4 protein, rat
  • Gata6 protein, rat
  • Transcription Factors
  • Sodium-Potassium-Exchanging ATPase