Immunoglobulin subclass distribution and binding characteristics of anti-GQ1b antibodies in Miller Fisher syndrome

J Neuroimmunol. 1994 Mar;50(2):159-65. doi: 10.1016/0165-5728(94)90042-6.


Circulating IgG antibodies to carbohydrate determinants on GQ1b ganglioside are found in the acute phase sera of patients with Miller Fisher syndrome, a variant of Guillain-Barré syndrome. Here we report that the IgG subclass distribution of the anti-GQ1b antibodies is mainly restricted to IgG1 and IgG3 antibodies, subclasses typically associated with a T cell-dependent immune response to protein antigens. This is highly unusual in that IgG responses to carbohydrate determinants are typically of the IgG2 subclass. Anti-GQ1b antibodies also have a limited ability to bind GQ1b in a membrane-like environment, particularly at body temperature. These data suggest that the antigen initiating the immune response in MFS is not likely GQ1b but an unidentified cross-reactive glycoprotein antigen(s). Similar results were obtained for anti-GM1 IgG antibodies in Guillain-Barré syndrome.

MeSH terms

  • Antibodies / classification
  • Antibodies / immunology*
  • Antibody Formation
  • Ataxia / immunology*
  • Body Temperature
  • Drug Carriers
  • Gangliosides / administration & dosage
  • Gangliosides / immunology*
  • Glycolipids / immunology
  • Humans
  • Immunoglobulin G / immunology
  • Immunoglobulins / immunology*
  • Liposomes
  • Nerve Growth Factors / immunology
  • Oligoclonal Bands
  • Ophthalmoplegia / immunology*
  • Reflex, Abnormal*
  • Syndrome


  • Antibodies
  • Drug Carriers
  • Gangliosides
  • Glycolipids
  • Immunoglobulin G
  • Immunoglobulins
  • Liposomes
  • Nerve Growth Factors
  • Oligoclonal Bands
  • GQ1b ganglioside