Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene

Nature. 1994 Jan 20;367(6460):236-42. doi: 10.1038/367236a0.

Abstract

The rum1+ gene is identified as a new regulator of G1 progression in fission yeast. It influences three aspects of G1 regulation: determination of the length of G1, dependence of S phase upon completion of mitosis, and restraint of mitosis until G1 is finished. We propose that it has a central role in regulating the G1 phase of the cell cycle.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • CDC2 Protein Kinase / metabolism
  • Cell Cycle / genetics*
  • Cyclin B
  • Cyclins / metabolism
  • DNA Replication / genetics
  • DNA, Fungal / biosynthesis
  • Fungal Proteins / genetics*
  • Fungal Proteins / physiology
  • G1 Phase / genetics
  • Genes, Fungal*
  • Models, Genetic
  • Molecular Sequence Data
  • Mutation
  • S Phase / genetics
  • Schizosaccharomyces / cytology
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces pombe Proteins*
  • Transformation, Genetic

Substances

  • Cyclin B
  • Cyclins
  • DNA, Fungal
  • Fungal Proteins
  • Rum1 protein, S pombe
  • Schizosaccharomyces pombe Proteins
  • CDC2 Protein Kinase

Associated data

  • GENBANK/X77730