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. 1993 Nov 12;162(1-2):43-5.
doi: 10.1016/0304-3940(93)90555-y.

The Non-Psychotropic Cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6- Tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) Attenuates N-methyl-D-aspartate Receptor-Mediated Neurotoxicity in Primary Cultures of Rat Forebrain

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The Non-Psychotropic Cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6- Tetrahydrocannabinol 1,1-dimethylheptyl (HU-211) Attenuates N-methyl-D-aspartate Receptor-Mediated Neurotoxicity in Primary Cultures of Rat Forebrain

V Nadler et al. Neurosci Lett. .

Abstract

The non-psychotropic cannabinoid (+)-(3S,4S)-7-hydroxy-delta 6- tetrahydrocannabinol 1,1-dimethylheptyl (HU-211), a stereoselective inhibitor of the N-methyl-D-aspartate (NMDA) receptor, protects primary cultures of rat forebrain against NMDA receptor-mediated neurotoxicity. Cell mortality produced by exposure for 10 min to NMDA or glutamate was reduced to approximately 18 or 27%, respectively, by application of 50 microM HU-211 for 10-15 min during or after exposure of cultures to excitatory amino acid. This effect of HU-211 was dependent on its concentration (EC50 = 8.7 +/- 4 microM). HU-211 also reduced the toxicity induced by brief exposure (10 min) to kinase or quisqualate, though less effectively. HU-211 may therefore prove useful as a non-psychoactive drug that protects against neurotoxicity mediated by the NMDA receptor.

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