Macrophage differentiation marker MyD88 is a member of the Toll/IL-1 receptor family

Biochem Biophys Res Commun. 1994 Feb 28;199(1):144-6. doi: 10.1006/bbrc.1994.1206.


The interleukin-1 receptor in mammals and the product of the Toll gene in Drosophila are related transmembrane receptors, involved in the activation of transcription factors of the rel family. Whereas the interleukin-1 receptor mediates the effects of interleukin-1 in the immune system, Toll is part of the system that determines dorsoventral polarity in the Drosophila embryo, although Toll may also have a function in the immune response in the fly. Here, I demonstrate that the open reading frame of MyD88, a gene induced in myeloid differentiation, is related to the cytoplasmic domains of the interleukin-1 receptor and the Toll gene product. The three related proteins define a family of signal transmitters, the original function of which may be to mediate responses in the immune system.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Antigens, Differentiation*
  • Cell Differentiation
  • Chickens
  • Drosophila Proteins
  • Drosophila melanogaster
  • Humans
  • Macrophages / cytology*
  • Mice
  • Molecular Sequence Data
  • Myeloid Differentiation Factor 88
  • Proteins / genetics*
  • Receptors, Immunologic*
  • Receptors, Interleukin-1 / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Signal Transduction


  • Adaptor Proteins, Signal Transducing
  • Antigens, Differentiation
  • Drosophila Proteins
  • MYD88 protein, human
  • Myd88 protein, Drosophila
  • Myd88 protein, mouse
  • Myeloid Differentiation Factor 88
  • Proteins
  • Receptors, Immunologic
  • Receptors, Interleukin-1

Associated data

  • GENBANK/M81846
  • PIR/P08953
  • PIR/P13504
  • PIR/P14778
  • PIR/P22366