Fibrils from synthetic amyloid-related peptides enhance development of experimental AA-amyloidosis in mice

Biochem Biophys Res Commun. 1994 Feb 28;199(1):306-12. doi: 10.1006/bbrc.1994.1229.

Abstract

Amyloid enhancing factor is an incompletely characterized activity of extracts from many amyloid-containing tissues and which greatly shortens the preamyloidotic phase during experimental induction of AA-amyloidosis. In this communication we show that amyloid-like fibrils made in vitro from synthetic peptides, corresponding to segments of amyloid fibril proteins, have amyloid enhancing factor-like activity. Thus, there is a possibility that amyloid enhancing factor activity depends on small fibrils serving as nucleation centers for fibril elongation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amyloid / chemistry*
  • Amyloid / pharmacology
  • Amyloidosis / etiology*
  • Amyloidosis / pathology
  • Animals
  • Female
  • Glycoproteins
  • Islet Amyloid Polypeptide
  • Mice
  • Molecular Sequence Data
  • Prealbumin / chemistry*
  • Prealbumin / pharmacology
  • Silver Nitrate / pharmacology
  • Spleen / pathology
  • Time Factors

Substances

  • Amyloid
  • Glycoproteins
  • Islet Amyloid Polypeptide
  • Prealbumin
  • amyloid enhancing factor
  • Silver Nitrate