No-go activity in the frontal association cortex of human subjects

Neurosci Res. 1993 Dec;18(3):249-52. doi: 10.1016/0168-0102(93)90062-u.

Abstract

'No-go potential', specific to the no-go reaction in go/no-go reaction-time hand movement with discrimination between different colour light stimuli, was recorded with electrodes chronically implanted in the prefrontal cortex of monkeys. Similar potentials were widely distributed over frontal-parietal parts of the human scalp on the same no-go reaction. In this report, MEG measurement was made over the scalp of five healthy subjects in order to localize current sources responsible for the scalp potential. We found in- and outflow of magnetic fields over the dorsolateral frontal parts of the head, contra- and ipsilateral to the operant hand. These magnetic fields were most reasonably interpreted to be due to current dipoles localized in the dorsolateral parts of frontal lobes in both contra- and ipsilateral hemispheres, presumably in the prefrontal-premotor areas. No-go decision and subsequent suppression of voluntary movements are suggested to be one of the functional features of the human frontal association cortex, as in the case of monkeys.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Evoked Potentials / physiology
  • Female
  • Frontal Lobe / physiology*
  • Hand / physiology
  • Humans
  • Magnetoencephalography
  • Male
  • Middle Aged
  • Movement / physiology
  • Reaction Time / physiology*